alexa Development and Validation of UV/ Visible Spectrophotom
e-ISSN: 2320-0812 p-ISSN: 2347-2340

Research & Reviews: Journal of Pharmaceutical Analysis
Open Access

Like us on: https://twitter.com/pharm_analysis
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Development and Validation of UV/ Visible Spectrophotometric Method for the Estimation of Oxcarbazepine in Bulk and Pharmaceutical Formulations.

Arti Mohan1*, and SK Ghosh2

1Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad 500015, Andhra Pradesh, India

2Department of Pharmaceutical Sciences, Dibrugarh university, Dibrugarh, Assam-786004, India

*Corresponding Author:
Arti Mohan
Malla reddy Institute of Pharmaceutical Sciences
Secunderabad 500015, Andhra Pradesh, India
Mobile: +91 9492173605

Received date: 28/08/2013; Revised date: 10/09/2013; Accepted date: 17/09/2013

 

Abstract

Oxcarbazepine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder A simple, sensitive, accurate and reproducible UV/visible spectrophotometric method was developed for the determination of Oxcarbazepine in bulk and pharmaceutical dosage forms. The solvent used was distilled water and wavelength corresponding to maximum absorbance for the drug was found at 256 nm. Drug obeyed Beer’s law in the concentration range of 10 - 80 μg/ml. with a correlation coefficient of 0.9995. The linear regression equation obtained was y=0.0093x+0.0064,where y is the absorbance and x is the concentration of the pure drug solution. The method was validated for several parameters such as Linearity, Accuracy, Precision and Robustness as per the ICH guidelines. The % recovery value which is close to 100% indicates reproducibility of the method and absence of interference of the excepients present in the formulation. The authors conclude that the proposed spectrophotometric method for the estimation of Oxcarbazepine can be used for routine analysis of Oxcarbazepine in bulk as well as in tablet dosage form.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords