alexa Development of Fast Dissolving Tablets Containing Ondansetron via Camphor Sublimation and its Characterization.
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Development of Fast Dissolving Tablets Containing Ondansetron via Camphor Sublimation and its Characterization.

Rajnikant M Suthar1*, Narendra P Chotai1, Digesh D Shah2, Rutvik M Thumar3, Hardik K Patel1, Mukesh B Jadeja4

AR College of Pharmacy and GH Patel Institute of Pharmacy, Vallabh Vidyanagar-388120, Anand, Gujarat, India

Sanofi – Aventis Pharmaceuticals Ltd, Ankaeshwar, Gujarat, India

Sahajanand Medical Technologies Pvt Ltd, Surat, Gujarat, India

Shivam Pharmaceutical and Education Research, Anand, Gujarat, India

*Corresponding Author:
Rajnikant M Suthar
AR College of Pharmacy and GH Patel Institute of Pharmacy, Vallabh Vidyanagar - 388120, Anand, Gujarat, India.
E-mail: [email protected]

Received date: 10/09/2012 Accepted date: 01/11/2012

 

 

Abstract

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dissolving tablets (FDTs) of ondansetron were prepared using different superdisintegrants by sublimation method. FDTs were evaluated for physicochemical properties and in vitro dissolution. The wetting time (10.5s) of formulation batch containing crospovidone (F2) was least and tablets showed fastest disintegration (3.2s). The drug release from FDTs containing superdisintegrants was more as compared to FDTs without superdisintegrant and it was found to be highest (98% drug release after 30 min) with formulation batch containing crospovidone (F2) so it can be concluded as promising formulation.

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