alexa Drug - Drug Solid Dispersion: A Unique Approach in Solu

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Drug - Drug Solid Dispersion: A Unique Approach in Solubility Enhancement

To read the full article Peer-reviewed Article PDF image


Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature indicates that physiological inert carriers have so far been used in solid dispersions for improving dissolution of poorly soluble drugs but in, novel approach will obviate the need for use of physiological inert carrier to improve dissolution of poorly soluble drugs and cost effective in developing formulations for clinical use.
Drug-drug Solid dispersion is a unique approach to present a poorly soluble drug in an extremely fine state of subdivision to the gastro intestinal fluids. It can be prepared by fusion, co-precipitation and kneading methods. Solid dispersion can form either a eutectic mixture or solid solution or glass solution or amorphous precipitation in a crystalline carrier or compound or complex formation.
Benefits of novel drug-drug solid dispersion not only for improving the dissolution of the poorly soluble drug without the use of soluble physiological inert carriers but also for the soluble drugs available in the fixed dose combination can be used to solid disperse the poorly soluble drugs.


Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version