Drug - Drug Solid Dispersion: A Unique Approach in Solubility Enhancement
Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature indicates that physiological inert carriers have so far been used in solid dispersions for improving dissolution of poorly soluble drugs but in, novel approach will obviate the need for use of physiological inert carrier to improve dissolution of poorly soluble drugs and cost effective in developing formulations for clinical use.
Drug-drug Solid dispersion is a unique approach to present a poorly soluble drug in an extremely fine state of subdivision to the gastro intestinal fluids. It can be prepared by fusion, co-precipitation and kneading methods. Solid dispersion can form either a eutectic mixture or solid solution or glass solution or amorphous precipitation in a crystalline carrier or compound or complex formation.
Benefits of novel drug-drug solid dispersion not only for improving the dissolution of the poorly soluble drug without the use of soluble physiological inert carriers but also for the soluble drugs available in the fixed dose combination can be used to solid disperse the poorly soluble drugs.