alexa Effect of Cardioactive Principle of Methanolic Extract
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Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Effect of Cardioactive Principle of Methanolic Extract of Allium Humile Leaves on Global Ischaemic Rat Heart

Yogita Dobhal1*, Versha Parcha2 and D.C.Dhasmana3

1Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences & Research, Balawala, Dehradun, Uttarakhand, India

2Department of Chemistry, Sardar Bhagwan Singh PG Institute of Biomedical Sciences & Research, Balawala, Dehradun, Uttarakhand, India

3Department of Pharmacology, H.I.M.S.Doiwala, Dehradun, Uttarakhand, India

*Corresponding Author:
Yogita Dobha
Department of Pharmaceutical Sciences
Sardar Bhagwan Singh PG Institute of Biomedical Sciences & Research
Balawala, Dehradun, Uttarakhand, India
Tel: 09410790829
E-mail: [email protected]

Received: 17/08/2015 Accepted: 07/09/2015

 

Abstract

Objective: In present study efficacy of active principle (AH-1) of Methanolic extract of Allium humile leaves has been evaluated to limit myocardial injury in ischaemic rat heart. Material and Methods: Various extracts of A. humile leaves were prepared using solvents of increasing polarity. Methanolic extract among all other extracts further purified using chromatographic technique results four major fractions A1, A2, A3, and A4. Cardioprotective potentials. Among these fractions A4 was found to be active fraction. AH-1 (active principle) was isolated from the fraction A4 using column chromatography technique and evaluated for Cardioprotective effect. Results: The Methanolic extract of A. humile leaves and further fraction A4 of Methanolic extract significantly prevented myocardial infarct size as compared with that of standard Ramipril in the study. From fraction A4 of Methanolic extract, the isolated active principle AH-1 showing cardio protective effect at dose level of 50 mg/kg body weight. Conclusion: The study suggests that AH-1 is active Cardioprotective principle of Methanolic extract of Allium humile leaves and was found significant (p˂0.05).
 

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