alexa Effect of the Methanolic Extract of Trichosanthes cucumerina Seed (Snake Gourd/Tomatoe) on Experimentally Enlarged Prostate Gland in Adult Wistar Rats
ISSN: 2319-9865

Research & Reviews: Journal of Medical and Health Sciences
Open Access

Like us on: https://twitter.com/MednHealScience
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of the Methanolic Extract of Trichosanthes cucumerina Seed (Snake Gourd/Tomatoe) on Experimentally Enlarged Prostate Gland in Adult Wistar Rats

Akinyemi RA*, Huthman IO, Adesanya OA, Akpan HB and Adefule AK

Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ikenne, Ogun-State.

*Corresponding Author:
Akinyemi RA
Department of Anatomy
Faculty of Basic Medical Sciences
Olabisi Onabanjo University
Ikenne, Ogun-State
Phone: +234-8036829240
Email: [email protected]

Received: 26/08/2012 Accepted: 14/11/2012

 

Abstract

To determine the effect caused by the methanolic extract of Trichosanthes cucumerina seed on experimentally enlarged prostate gland in adult Wistar rats. We included 20 adult male Wistar rats, of 4 groups (Normal control NCTRL, Hormone treated control HTC, High dose of extract HDT/C, Low dose of extract LDT/C) with each group comprising of 5 animals each, with individual rats weighing between 150g-320g. The prostatic hyperplasia was achieved by the simultaneous induction of 400ng/ml of Estradiol and 1250ng/ml of Testosterone (with respect to the subject’s body weight), which were administered via the inguinal region for a period of 3 weeks (in alternate days). After the period of hormonal administration, two of the subjects from groups NC and HTC were sacrificed in other to appreciate the prostatic hyperplasia in the HTC group as compared with the NC. Furthermore, with the methanolic extract of the plant’s seed, the animals grouped in HD/TC and LDT/C was treated with respect to their body weight, for a period of 3 weeks. After which, the animals were sacrificed and the prostate glands excised for histological studies. All results were expressed as Mean ± Standard Deviation (S.D) for each group. All grouped data were statistically evaluated using SPSS 15.0 software. Hypothesis testing methods included the independent – samples t–test. Statistical significance was set at p<0.05. The experimentally induced enlargement was able to be reversed back to normal due to the effect of the methanolic extracts of Trichosanthes cucumerina seed. The combined administration of Testosterone and Estradiol caused an enlargement in the prostate due to an increase in the prostatic acini, tubules and epithelium size however there was a reversal to the normal state with the number of the prostatic acini and tubules per unit area reduced after the dosage (high and low) administration of the extract

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords