alexa Effects of Microgravity on the Phenotype, Genome and Transcriptome of Streptococcus pneumonia
E- ISSN: 2320 - 3528
P- ISSN: 2347 - 2286

Research & Reviews: Journal of Microbiology and Biotechnology
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Research Article

Effects of Microgravity on the Phenotype, Genome and Transcriptome of Streptococcus pneumonia

Jia Li1,2, Yinghua Guo1, Guogang Xu1, Xuelin Zhang1, Lei Pan1, Hong Zhong1, Chou Xu1,Changting Liu1*

1Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing, China

2School of Medicine, Nankai University, Tianjin, P R China

*Corresponding Author:
Changting Liu
Nanlou Respiratory Diseases Department
Chinese PLA General Hospital
No. 28 Fuxing Road
Beijing 100853, P R China
Phone: 86-010-6687-6272
E-mail: [email protected]

Received date: 18/05/2016; Accepted date: 28/06/2016; Published date: 05/07/2016



Objective: Microgravity can influence pathogenic bacteria by changing their various biological characteristics. However, how microgravity affects Streptococcus pneumoniae as well as the relevant mechanisms remain unclear. Methods: A multiple drug resistant Streptococcus pneumoniae strain was cultured in a microgravity or gravity environment for 16 h. Subsequently, various phenotypic assays were performed, including those for morphology, growth curves, biofilm formation and acid and base stress. A combined genomic and transcriptomic analysis was performed. Results: Compared with gravity and the parental strain, the morphology, growth curve and biofilm formation of the microgravity strain did not change, whereas the microgravity strain had increased resistance to weak acid and base solutions and lost the ability to utilize glucuronamide. Comparative genomic and transcriptomic analyses revealed that the microgravity strain had changes in gene expression related to metabolism, cell wall/capsule and cell defense mechanisms. Conclusion: Our study reveals microgravity has a significant influence on metabolism and adaptation in the Streptococcus pneumoniae, which exhibit great flexibility and adaptability to survive successfully via the regulation of multiple physiological functions and cellular pathways. It may provide new understanding of space microbiology.


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