alexa Evaluation of Diuretic Activity of Extracts of Gentiana oliveri and Gentianine in Rats
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Evaluation of Diuretic Activity of Extracts of Gentiana oliveri and Gentianine in Rats

Arsala Mansoor1, Sohaib Huda2 and Mudassir Asrar3*

1Department of Biochemistry, Bolan Medical College, Quetta. Pakistan

2Liaquat National Medical College, Karachi, Pakistan

3Department of Botany, University of Baluchistan, Quetta, Pakistan

Corresponding Author:
Mudassir Asrar
Assistant Professor
Department of Botany
University of Baluchistan, Quetta, Pakistan
E-mail: [email protected]

Received date: 26/11/2015; Accepted date: 22/12/2015; Published date: 29/12/2015



Biological and pharmacological assays of the extracts of Gentiana oliveri and its alkaloid gentianine proved to be highly efficacious. Extracts of Gentiana oliveri and gentianine were evaluated for diuretic activity in normotensive, rats. Oral administration of all the fractions enhanced ion excretion. A dose-dependent diuresis and electrolytes excretion was also observed when dose by gentianine. There was marked increase in Na+, K+ and Cl- ion excretion in the aqueous extract as compared to control and furosemide. Significant increase in urinary excretion was produced by pure alkaloid (P<0.04), ethanolic extract (P<0.03), aqueous extract (P<0.01) and furosemide (P<0.001). Gentianine could be developed as a safe antihypertensive drug.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version