alexa Formulation and Evaluation of Dicloxacillin Sodium Floating Tablets.
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Formulation and Evaluation of Dicloxacillin Sodium Floating Tablets.

Murari Pavan1*, Prasanth VV1, Abhishek Sharma1, Ajay Chauhan1, Rinku Mathappan2, and Sam T Mathew3

Department of Pharmaceutics, Gautham College of Pharmacy, Bangalore 560 032, Karnataka, India.

Department of Pharmacognosy, Gautham College of Pharmacy, Bangalore, Karnataka, 560 032, India.

Regulatory Affairs and Medical Writing, Biocon Pvt Ltd, Bangalore 560 100, India.

*Corresponding Author:
Department of Pharmaceutics, Gautham College of Pharmacy, Bangalore 560 032, Karnataka, India

Received date: 11/01/2014 Accepted date: 05/03/2014 Revised date: 27/02/2014

 

 

Abstract

The purpose of this research work was to develop gastroretentive drug delivery system of Dicloxacillin sodium. Floating tablets were prepared by wet granulation method using gas generating agents such as sodium bicarbonate and citric acid anhydrous, like Hydroxypropyl methylcellulose (HPMC K100M), Xanthan gum, Sodiumcarboxy methylcellulose (NaCMC) and Microcrystalline cellulose (MCC). Dicloxacillin sodium floating tablets were prepared by wet granulation method were found to be good without chipping, capping and sticking. The drug content was uniform in all the tablet formulations indicating uniform distribution of drug within the matrices. All the prepared batches showed satisfactory floating lag time and total floating time found to be more than 12 h. Formulation F14 showed desired drug release selected as a best formulation and subjected to stability studies for 3 months showed that formulation is intact without interaction. Finally optimized formulation F14 complying with all properties of floating tablets and found to be satisfactory.

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