alexa Formulation and Evaluation of Floatable In-situ Gel for
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Formulation and Evaluation of Floatable In-situ Gel for Stomach-Specific Drug Delivery of Vanlafaxine HCL.

Mahak Shaikh, Aarti Mandloi, Vishnu Yadav, Gopkumar P. and Sridevi G*

GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone, Madhya Pradesh – 451228, India

*Corresponding Author:
GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone, Madhya Pradesh – 451228, India.

Received date: 21/01/2014 Accepted date: 05/03/2014 Revised date: 28/02/2014

 

 

Abstract

The present investigation deals with the formulation and evaluation of sodium alginate and HPMC based floating oral in-situ gel of Vanlafaxine HCL. Sodium alginate and HPMC were used as a polymer and CaCO3 was used as a cross-linking agent to form in-situ gels. The drug gets released in sustained and controlled manner from these types of formulations for prolonged duration thus reduces the dosing frequency of the drug. Formulation method of present study utilizes the polymers that exhibit sol-to-gel phase transition due to change in specific physicochemical parameters. Developed formulations were evaluated for their suitability to control the drug release and ease of administration by measuring the amount of drug entrapped, floatation duration, rate of drug release and pH and viscosity during sol gel transition etc. Results of the study indicated among the different batches of formulations with range of polymeric concentration and gelling stimuli, the formulation batch F1 was most suitable preparation being able to control the drug release for 24hrs duration with administration and physiological suitability in terms of pH and Viscosity. Thus results of the study concluded that very useful antidepressant drugs like Vanlafaxine HCL can be reformulated into more patient friendly and therapeutically beneficial formulations using these types of oral in-situ floatable gel systems, which reduces manufacturing cost and duration.

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