alexa Formulation and Evaluation of Mucoadhesive Buccal Film
e-ISSN: 2347-7857 p-ISSN: 2347-7849

Research & Reviews: Journal of Pharmaceutics and Nanotechnology
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Research Article

Formulation and Evaluation of Mucoadhesive Buccal Film of Lisinopril.

Ann Rose Augusthy1*, Vipin KV2, Sarath Chandran C2, Thushara MV 2, Shahin Muhammed TK3

1Department of Pharmaceutics, Academy of Pharmaceutical Sciences, Pariyaram Medical College, Pariyaram, Kannur District, Kerala, India

2Department of Pharmaceutics, Academy of Pharmaceutical Sciences Pariyaram, Kerala, India

3Department of Pharmaceutical Chemistry, Academy of Pharmaceutical Sciences, Pariyaram, Kerala, India

*Corresponding Author:
Ann Rose Augusthy
Department of Pharmaceutics, Academy of Pharmaceutical Sciences, Pariyaram Medical College, Pariyaram, Kannur District, Kerala, India
Mobile: +91 9846895141

Received date: 07 October 2013 Accepted date: 31 December 2013

 

Abstract

The mucoadhesive buccal film of Lisinopril were prepared by using various polymers like HPMC K4M, sodium CMC, PVP K30, eudragit RL 100, carbopol 934 by solvent casting method and evaluated for physical appearance, thickness, weight uniformity, folding endurance ,percentage swelling index, percentage moisture content, drug diffusion studies and drug content estimation.Among all formulation, buccal film prepared with 4% HPMC K4M,0.5% PVP K30 1% Sodium CMC and 5% tween 80 as surfactant exhibited better drug release, drug content estimation and maximum percentage of swelling index. The drug release could be extended up to 8 hr and a drug release of 98.41% was observed. FTIR studies revealed that drug and excipients are compatible. Stability study of selected optimised formulations were done as per ICH guidelines for 1 month, which revealed that no significant change with respect to the evaluations conducted before stability charging.

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