alexa Formulation and Evaluation of Muco-adhesive In-situ Gel for Site-Specific Delivery of Clotrimazole.
e-ISSN: 2347-7857 p-ISSN: 2347-7849

Research & Reviews: Journal of Pharmaceutics and Nanotechnology
Open Access

Like us on: https://twitter.com/PharmaNanotech
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Formulation and Evaluation of Muco-adhesive In-situ Gel for Site-Specific Delivery of Clotrimazole.

Jeevan Sen, Sujit Pillai, Gopkumar P, and Sridevi G*

GRY Institute of Pharmacy, Borawan, Khargone - 451228, India

*Corresponding Author:
Sridevi G
GRY Institute of Pharmacy, Borawan, Khargone - 451228, India

Received date: 29 April 2014 Accepted date: 22 May 2014

 

Abstract

Present research is about the In-situ gels for site specific delivery. In the present work, formulations with chitosan, bioadhesive and permeation enhancer and gellan gum ion activable gelling polymer and temperature sensitive polymeric systems was used for In-situ geliling. The developed formulations was characterized for various in-vitro parameters e.g. clarity, pH, isotonicity, viscosity, drug release profile, statistical release kinetics, bioadhesive force, retention time, microbial efficacy, irritation test and stability studies. Conventional topical application of clotrimazole to skin may cause localized irritation of the skin with a mild burning sensation, redness and itching. The entrapment of drug in polymer matrix was viewed to help in the localized delivery of the drug and an improved availability of the drug at the site and reduce the local side effects of drug. Therefore, it was envisaged to develop the mucoadhesive gels for topical delivery system which gives better patient compliance, controlled delivery of drug, reduce the local side effects of drug. The developed formulation was found to be non-irritant, bioadhesive with good retention properties. Developed formulation shows matrix model release kinetic. The developed formulation is thus a viable alternative to conventional vaginal dosage forms.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords