alexa Formulation and Evaluation of Propranolol Hydrochloride Microsphers.
e-ISSN: 2347-7857 p-ISSN: 2347-7849

Research & Reviews: Journal of Pharmaceutics and Nanotechnology
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Research Article

Formulation and Evaluation of Propranolol Hydrochloride Microsphers.

Kanaka Durga Vikash Guntiboyina1*, Sanjay P Umachigi1, Prasanth VV1, Abhishek Sharma1, Rinku Mathappan2, and Sam T Mathew3

1Department of Pharmaceutics, Gautham College of Pharmacy, Bangalore, 560 032, India

2Department of Pharmacognosy, Gautham College of Pharmacy, Bangalore, 560 032, India

3Regulatory affairs and Medical writing, Biocon Pvt Ltd, Bangalore 560 100, India

*Corresponding Author:
Kanaka Durga Vikash Guntiboyina
Department of Pharmaceutics, Gautham College of Pharmacy Sulthan Palaya, R.T Nagar Post Bangalore, Karnataka, India

Received date: 03 January 2014 Accepted date: 04 March 2014

 

Abstract

Six formulations of Propranolol Hydrochloride loaded microspheres were prepared by non-aqueous emulsification-solvent evaporation technique.The percentageyield of the microspheres varied from 75.33 ± 0.006 and 92.21 ± 0.003. The entrapment efficiency of Propranolol Hydrochloride microspheres were ranged between 79.7 ± 0.02 and 85.87 ± 0.03 %. It was reported that the encapsulation efficiency depends on the solubility of the drug in the solvent.The mean particle size of the prepared formulation ranged from 256.56 ± 0.07 and 382.77 ± 0.05μm. The drug content of the prepared formulation ranged between 76.19 ± 2.5 and 87.74 ± 3.1%. The swelling indices of the microspheres were high (up to 0.89 ± 0.02 for F4) and varied between the formulations.The maximum in vitro release was evaluated to be 96.55 % over a period of 14 h for formulation F4. The in vitro drug release increased in the following order: F1< F6< F3< F5< F2< F4.Formulations F6 provided good fit to the Higuchi model and the remaining formulations showed the best fit to the Korsmeyer-Peppas model.Scanning electron micrographs of selected formulation indicated that the microspheres were discrete, uniform and spherical with a smooth surface. During at the end of accelerated stability studies the tested formulation (F4) showed non-significantly different drug content, entrapment efficiency and in vitro drug release from that observed at the beginning of the study. No color changes were also observed during the study period.

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