alexa In- vitro Anti-Cancer Screening of Solanumindicum Rhus succedanea, Rheum emodiand Gardenia gummifera Medicinal Plants in Cancer Cells.
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

In- vitro Anti-Cancer Screening of Solanumindicum Rhus succedanea, Rheum emodiand Gardenia gummifera Medicinal Plants in Cancer Cells.

Sumantha Malur Gopalakrishna1, Girisha Sirangala Thimappa1*, Ramesh Puttalingaiah Thylur2, Yogisha Shivanna2, and Anand Sreenivasan2.

1Dept of Microbiology and Biotechnology, Bangalore University, Bangalore 560056, Karnataka, India.

2Drug Discovery Research Lab, Skanda Life Sciences Pvt Ltd, Bangalore 560091, Karnataka, India.

 

Corresponding Author:
Girisha Sirangala Thimappa
Department of Microbiology and Biotechnology
Bangalore University
Bangalore 560056, India
Mobile: +91 9448439030

Received: 09/09/2014; Revised: 22/09/2014; Accepted: 27/09/2014

 

 

Abstract

The anticancer activities of Solanumindicum, Rhus succedaneum, Rheum emodi, and Gardenia gummifera medicinal plants from the methanolic extracts were determined by using in-vitroMTT cytotoxicity assay in various cancer cell lines human non-small cell lung carcinoma(H1975), prostatecarcinoma (PC-3and DU145), colorectal carcinoma (HCT116) and malignant melanoma (A375). The in-vitrocytotoxicity assay revealed that S. indicum, R. succedanea, R. emodi and G. gummifera extracts had strongest cytotoxicity with IC50 of 8.48 ∞g/ml,24.5∞g/ml, 28.24∞g/ml and 28.61∞g/ml respectively in DU145 cells and also with IC50 of 11.18∞g/ml, 11.04 ∞g/ml, 11.05 ∞g/ml and 23.03∞g/ml respectively in PC-3 cells. Whereas these extracts exhibited cytotoxicity with IC50 of 9.03∞g/ml, 7.71∞g/ml, 15.95 ∞g/ml and 11.71∞g/ml respectively in H1975 cells. Similarly all these extracts showed cytotoxicity with IC50 of 17.58∞g/ml,8.87∞g/ml,19.31∞g/ml and 11.67 ∞g/ml respectively in HCT116 cells. Finally methanolic extracts of these extracts exhibited cytotoxicity with IC5027.94 ∞g/ml, 13.13∞g/ml, 11.05 ∞g/ml and 7.816∞g/ml respectively in A375 cells. Our results revealed that methanolic extract of S. indicum, R. succedanea, R. emodi, and G. gummifera had profound cytotoxic effectand further studies to be initiated for potential herbal formulations to be used as an alternative of chemotherapeutic drugs due to less toxic to normal cells.

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