alexa Interaction of Adrenal and Gonadal Axes during Stress in Males
e-ISSN: 2321-6190 p-ISSN: 2347-2294

Research & Reviews: Journal of Zoological Sciences
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Review Article

Interaction of Adrenal and Gonadal Axes during Stress in Males

Socorro Retana-Marquez1*, Lizbeth Juarez-Rojas1 and Fahiel Casillas2,3

1Departamento de Biologia de la Reproduccion, Division de Ciencias de la Salud y Biologicas. Universidad Autonoma Metropolitana-Iztapalapa, DF 09340, Mexico

2Departamento de Ciencias de la Salud, Division de Ciencias de la Salud y Biologicas. Universidad Autonoma Metropolitana - Iztapalapa, DF 09340, Mexico

3Doctorado Biologicas y en Ciencias de la Salud, Division de Ciencias de la Salud y biologicas . Universidad Autonoma Metropolitana-Iztapalapa, DF 09340 , Mexico

*Corresponding Author:
Socorro Retana-Marquez
Departamento de Biologia de la Reproduccion
Division de Ciencias Biologicas y de la Salud
Universidad Autonoma Metropolitana-Iztapalapa
09340 DF, Mexico
Tel: 52-55-58044701
Fax: 52-55-58044930
E-mail: [email protected]

Received date: November 06, 2015; Accepted date: December 18, 2015; Published date: December 23, 2016



In mammals, chronic exposure to different types of stressors, its strength and duration has long been recognized as a disruptive factor in the reproductive function. In males, stress has a suppressive effect on testosterone secretion, spermatogenesis and sexual behavior. Severe suppression of reproduction appears to be caused by hormones secreted when the hypothalamic-pituitary-adrenal (HPA) axis is activated during stress. Since Hans Selye suggested in 1946 that chronic stress increases activity in the HPA axis and at the same time suppresses activity in the hypothalamic-pituitary-gonadal (HGA) axis, there have been several studies demonstrating this antagonistic relationship. The centrally mediated inhibition of gonadotropin releasing hormone (GnRH) by the hormones of the HPA, such as corticotropin releasing hormone (CRH), β-endorphins, and glucocorticoids, as well as the gonadotropin inhibitory hormone (GnIH), the decrease in pituitary responsiveness to GnRH, and the direct effects of stress-hormones on testis leading to the reduction in testosterone secretion are discussed. The aim of this review is focused on the suppression of testicular axis caused by stress, as well as its reproductive consequences in fertility and sexual behavior in males.


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