Multidrug Resistance for Cancer Treatment: Delivery of Ursolic Acid and Caffeine by Poly (Lactic-Co-Glycolic Acid) NanoparticlesJose Merlin JP1*, Venkadesh B2, Sheeja S Rajan3 and Subramanian P4
- *Corresponding Author:
- Jose Merlin JP
PG and Research Department of Zoology
Muslim arts college, Tamilnadu, India
Tel: +91 9442094520
Received date: April 13, 2017; Accepted date: April 21, 2017; Published date: April 30, 2017
Citation: Merlin JJP, Venkadesh B, Rajan SS, Subramanian P (2017) Multidrug Resistance for Cancer Treatment: Delivery of Ursolic Acid and Caffeine by Poly (Lactic-Co-Glycolic Acid) Nanoparticles. J Gastrointest Cancer Stromal Tumor 2:113 doi: 10.4172/2572-4126.1000113
Copyright: © 2017 Merlin JJP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Multidrug-resistant (MDR) cancer may be treated using combinations of encapsulated cytotoxic drugs or chemo sensitizers. To optimize for the effectiveness of this combinational approach poly (lactic-o-glycolic acid) nanoparticle formulations capable of delivering a cytotoxic drug or chemo sensitizers, ursolic acid (UA) and Caffeine (Caf) combination were prepared. The system can be used for targeting, controlled drug delivery and also imaging of cancer cells. The prepared nanoparticles were characterized using DLS, TEM, XRD and FT-IR a studies. The drug loaded nanoparticles exhibited significant antitumor effects and high tumour targeting ability towards HT29 human colon cancer cells. The aforementioned results indicated that the drug loaded nanoparticle prepared in the study had a specific interaction with colon cells. Therefore, the prepared nanoparticle may be used as a potential drug delivery system for the targeted delivery to colon cancers.