alexa Novel Approaches to Colon Targeted Drug Delivery System: A Review.
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Novel Approaches to Colon Targeted Drug Delivery System: A Review.

Nemade Mahesh S*, Chaudhari Rajesh Y, and Patil Vijay R

TVES’s HLMC College of Pharmacy, Faizpur, India.

*Corresponding Author:
TVES’s HLMC College of Pharmacy, Faizpur, India.

Received date: 25/02/2014 Accepted date: 17/03/2014 Published date: 11/03/2014




Targeted drug delivery to the colon is being explored not only for local colonic pathologies, but also for systemic delivery of drugs like proteins and peptides. Local delivery could, allow topical treatment of inflammatory bowel disease. Treatment could be made more effective for drugs to be targeted directly on the colon site and systemic side effects could be reduced. Colon specific systems might also allow oral administration of peptide and protein drugs, which are normally degraded in the upper parts of the gastrointestinal tract. The treatment of disorders of the large intestine (colon), such as Colon cancer, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) i.e. Ulcerative colitis and Crohn’s disease, Diverticulitis and other colon diseases, where it is necessary to attain a high concentration of active therapeutic agent, may be efficiently achieved by colon specific delivery. This is also a potential site for the treatment of diseases sensitive to circadian rhythms such as asthma, angina, hypertension and arthritis. Primary approaches for colon specific drug delivery (CDDS), which includes prodrugs, pH and time dependent systems and microbially triggered drug delivery system achieved limited success and having limitations. Newly developed CDDS, which includes pressure controlled colonic delivery capsules (PCDCS) and osmotic controlled drug delivery are unique in terms of achieving in-vivo site specificity and feasibility of manufacturing process. The focus of this review is to provide detailed insight into the various colon diseases, approaches used to target the therapeutic agents specifically to the colon.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version