alexa Pallidifloside D from Smilax riparia Enhanced Allopurin
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Research Article

Pallidifloside D from Smilax riparia Enhanced Allopurinol Effects in Hyperuricemia Mice

Xiao-Hui Wu1,2* Yi He1, Chao Mi3, Jun Zhang1, Shu-Qing Wang1, Fei Yu1, Samantha Anderson2 and Yan- Wen Zhang1*

1Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China

2Tang Center for Herbal Medicine Research, University of Chicago, Chicago, Illinois 60637, USA

3College of Public Health and Communication, Tianjin Medical University, Tianjin 300070, China

Corresponding Authors:
IXiao-Hui Wu
Tianjin Key Laboratory on Technologies Enabling Development of Clinical
Therapeutics and Diagnostics
College of Pharmacy, Tianjin Medical University, Tianjin 300070, China
Tel: +86-22-60357206
Fax: +86- 22-60357208
E-mail: [email protected]
Yan-Wen Zhang
College of Public Health and Communication
Tianjin Medical University
Tianjin 300070, China
E-mail: [email protected]

Received date: 01/01/2015 Accepted date: 09/07/2015 Published date: 14/07/2015

 

Abstract

Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinol’s effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D was linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions.

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