alexa Pallidifloside D from Smilax riparia Enhanced Allopurin

Research & Reviews: Journal of Medicinal & Organic Chemistry
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Pallidifloside D from Smilax riparia Enhanced Allopurinol Effects in Hyperuricemia Mice

Xiao-Hui Wu1,2* Yi He1, Chao Mi3, Jun Zhang1, Shu-Qing Wang1, Fei Yu1, Samantha Anderson2 and Yan- Wen Zhang1*

1Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China

2Tang Center for Herbal Medicine Research, University of Chicago, Chicago, Illinois 60637, USA

3College of Public Health and Communication, Tianjin Medical University, Tianjin 300070, China

Corresponding Authors:
IXiao-Hui Wu
Tianjin Key Laboratory on Technologies Enabling Development of Clinical
Therapeutics and Diagnostics
College of Pharmacy, Tianjin Medical University, Tianjin 300070, China
Tel: +86-22-60357206
Fax: +86- 22-60357208
E-mail: [email protected]
Yan-Wen Zhang
College of Public Health and Communication
Tianjin Medical University
Tianjin 300070, China
E-mail: [email protected]

Received date: 01/01/2015 Accepted date: 09/07/2015 Published date: 14/07/2015



Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinol’s effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D was linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version