pH sensors and ion Transporters: Potential therapeutic targets for acid-base disorders
Kimberly F. Atkinson, Surya M. Nauli*
Department of Biomedical & Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.
- *Corresponding Author:
- Surya M. Nauli
Department of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.
E-mail: [email protected]; [email protected]
Received date: February 18, 2016; Accepted date: March 27, 2016; Published date: March 31, 2016
Regulation of pH is critical for physiological processes. Maintenance of acid-base homeostasis is tightly regulated by the renal and respiratory systems. However, fluctuations in extracellular pH are also sensed by other organ systems. Ion transporter activity to modify the amount of acid (H+ and CO2) and bicarbonate HCO3- is therefore actively maintained within the kidney and lung. This review describes acid-base disorders (acidosis and alkalosis) and highlights the importance of pH sensors and ion transporters that may be potential therapeutic targets for treatment of acid-base disorders. Specifically, the renal pH sensors proline-rich tyrosine kinase- 2 (Pyk2) and G-protein coupled receptor-4 (GPR4) are discussed here.