alexa Prodrugs as Emerging Tool for Increasing Safety Profile of Existing Drugs
e-ISSN: 2319-9849

Research & Reviews: Journal of Chemistry
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Editorial

Prodrugs as Emerging Tool for Increasing Safety Profile of Existing Drugs

Redasani VK*

R. C. Patel Institute of Pharmaceutical Education & Research,Shirpur, Dhule, Maharashtra India

*Corresponding Author:
Redasani VK
R. C. Patel Institute of Pharmaceutical Education& Research
Shirpur, Dhule, Maharashtra India
E-mail: [email protected]

Received date: 01/08/2015; Accepted date: 07/08/2015; Published date: 13/08/2015

 

Abstract

The process of drug discovery is never ending, time consuming and expensive one. With the openings of high throughput screening and computer aided techniques; even though various drugs are identifying but the final outcome is very less. When a new chemical entity has some barrier/limitation to utility, it may not be developed as a therapeutic agent. This fact is attributed to the undesirable physico-chemical properties of the existing drug molecule. The steady improvement in the physicochemical, biopharmaceutical and/or pharmacokinetic properties of pharmacologically active compounds is due implementation of a prodrug strategy. Thus prodrug designing leads to raising the therapeutic effectiveness of medicinal compound through derivatization. Even though numerous prodrugs have been designed and developed but safety of promoiety is always the great concern. The acceptance of prodrug is dependent on proper selection of promoiety. A wide variety of promoieties have been used to overcome liabilities associated with drugs. The selection of promoiety depends on the purpose of the prodrug, type of functional groups available on the parent drug, chemical and enzymatic conversion mechanisms of prodrug to parent drug, safety of the promoiety, and ease of manufacturing.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords