Pulsatile Drug Delivery with Press Coated Techniques
Pulsatile drug delivery systems (PDDS) have attracted attraction because of their multiple benefits over conventional dosage forms. They deliver the drug at the right time, at the right site of action and in the right amount, which provides more benefit than conventional dosage and increased patient compliance. The past several decades have seen the development of many controlled-release preparations constant release rates to maintain drug concentrations in the human body, according of the patient's physiological condition. Person to person different physiological and biochemical conditions during any 24 h period, due to the circadian rhythm, and thus, the constant delivery of a drug into the body. Pulsatile drug delivery system which promises the predetermined Lag-time followed by the immediate release of drug. So optimizing the therapeutic effect while minimizing side effects. Various methods describes in review in which press coating technique is a simple and unique technology used to provide tablets with a programmable lag phase, followed by a fast, or rate-controlled, drug release after administration. The technique offers many advantages, and no special coating solvent or coating equipment is required for manufacturing this type of tablet. The contents of this article include biological rhythms and the reasons for using pulsatile drug delivery for disease treatment, and press-coated delivery techniques, factors affecting the performance and drug release characteristics of press-coated delivery systems.