Role of Glimepiride Novel Sulfonylurea in the Management of Type 2 Diabetes Mellitus
Background: Diabetes mellitus (DM) is probably one of the oldest diseases known to man. The number of people with type 2 DM is increasing in every country with 80% of people with DM living in low- and middle-income countries. Type 2 Diabetes mellitus is the most common form of diabetes mellitus characterized by hyperglycemia, insulin resistance, and relative insulin deficiency. There are many effective treatment options available for the type 2 diabetes mellitus. But sulfonylureas still play a primary role in pharmacologic management of type 2 diabetes. Therefore we evaluated the effect of Glimepiride on fasting blood sugar level in patients of type 2 diabetes mellitus. Objective: To find out the effect of Glimepiride on fasting blood sugar level in type 2 diabetes mellitus Patients. Material & Methods: This study was conducted by the Department of Pharmacology in association with Department of Medicine at Maharishi Markandeshwar Institute of Medical Sciences & Research (MMIMSR), Mullana Ambala. Total 25 patients were selected for the study and these patients were administered Glimepiride in dose range of 1-6 mg/day, for 24 weeks. Statistical Analysis: statistical analysis was done by Student’s “t”- test. Result: During the study it was found that there was a significant reduction in fasting blood sugar score (p<0.05) after 24 weeks. Conclusion: Glimepiride play an important role in type 2 diabetes patients because glimepiride effectively reduced fasting blood sugar.