alexa Schiff Bases Derived from 2-Hydroxy and 2-Methoxy Napht
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

Schiff Bases Derived from 2-Hydroxy and 2-Methoxy Naphthaldehyde: Exploration of In Silico Docking, DNA Cleavage, Antibacterial Activities and SAR

Devika BR1, Girija CR2* and Ramakrishna R3

1Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India

2SSMRV Degree College, Jayanagar, Bangalore, Karnataka, India

3Government Science College, Bangalore, Karnataka, India

Corresponding Author:
Girija CR
SSMRV Degree College Jayanagar
Bangalore, Karnataka, India
Tel: +919886419952
E-mail: [email protected]

Received date: April 24, 2017; Accepted date: May 24, 2017; Published date: May 31, 2017

Citation: Devika BR, Girija CR, Ramakrishna R (2017) Schiff Bases Derived from 2-Hydroxy and 2-Methoxy Naphthaldehyde: Exploration of In Silico Docking, DNA Cleavage, Antibacterial Activities and SAR. Mod Chem appl 5:219. doi:10.4172/2329-6798.1000219

Copyright: © 2017 Devika BR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Antibacterial activities, molecular docking and DNA cleavage activities of five structurally related Schiff bases were performed and their structure activity relationship was studied. Antibacterial activities of these compounds against gram-negative and gram-positive bacteria were evaluated by using well diffusion method and the molecule 1-[(E)-(4- hydroxyphenyl)iminomethyl]naphthalene-2-ol which carries two hydroxyl functional groups was observed as one of the most dynamic antibacterial agents. The antibacterial activities of this molecule was compared with an earlier research work and concluded that the antimicrobial activities of these Schiff base analogues can be improved by introducing OH groups in their core structure. Docking interactions were investigated against p55blk kinase protein. The compound 1-[(E)-(3-nitrophenyl)iminomethyl]naphthalene-2-ol exhibited good docking proficiency with 24 interactions based on statistical potentials and the compound (E)-1-(2-methoxy-1-naphthyl)-N-(3-nitro phenyl)methanimine showed significant docking interaction based on hydrogen bonding. DNA cleavage efficiency of all the Schiff bases was investigated using Lambda DNA by gel electrophoresis method.

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