alexa Studies on the Production of (E,E)-geranyllinalool in E. coli
E- ISSN: 2320 - 3528
P- ISSN: 2347 - 2286

Research & Reviews: Journal of Microbiology and Biotechnology
Open Access

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Research Article

Studies on the Production of (E,E)-geranyllinalool in E. coli

Shuai Wang1#, Hongwei Liu1#, Yanfang Yang1, Wei Fan1, Iain W. Wilson2, Qiang Wang3* and Deyou Qiu1*

1State Key Laboratory of Tree Genetics and Breeding, The Research Institute of Forestry, Chinese Academy of Forestry, Beijing, PR China

2CSIRO Agriculture Flagship, Canberra ACT, Australia

3College of Agronomy, Sichuan Agricultural University, Chengdu, PR China

4These authors contributed equally to this work.

*Corresponding Author:
Qiang Wang
College of Agronomy, Sichuan Agricultural University, Chengdu, PR China
Tel: 028-86290170
E-mail: [email protected]

Deyou Qiu
The Research Institute of Forestry, CAF, Beijing, PR China
Tel: 010-62889641
E-mail: [email protected]

Received date: 08 July 2014; Accepted date: 07 September 2015; Published date: 10 September 2015



(E,E)-geranyllinalool (GL) can be used as an intermediate for chemical synthesis of several drugs as well as an insect pheromone and spice. Traditionally, (E)-nerolidol was used as a substrate to make (E,E)- geranyllinalool but the yield was low due to the multiple and complicated chemical synthesis processes. In this study, the (E,E)-geranyllinalool synthase gene (AtGES, At1g61120) from Arabidopsis thaliana was inserted into the Escherichia coli vector pET30a(+). E. coli strains containing plasmids pIRS and pGG that enable the synthesis of (E,E)-geranyllinalool precursors, when co-transformed with AtGES, were able to synthesize (E,E)- geranyllinalool with a yield up to 31.42 mg/L. This is the first report about the production of (E,E)-geranyllinalool by manipulation of multiple genes of its biosynthesis pathway in E. coli. Our results may facilitate metabolic engineering towards more cost-effective production of (E,E)-geranyllinalool in microorganisms.


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