alexa Synthesis and Anti-inflammatory Evaluation of 1,2,4 Tri
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Research & Reviews: Journal of Chemistry
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Research Article

Synthesis and Anti-inflammatory Evaluation of 1,2,4 Triazole Derivatives

Meenakshi Virmani1*, Sabir Hussain2

1Department of Chemistry, Shri Jagdish Prasad Jhabarmal Tibrewala University, Jhunjhunu(333001), Churu Road, Chudela (Rajasthan), India.

2Department of Chemistry, Echelon Institute of Tech. (M.D University, Rohtak) Faridabad, Haryana 121106, India

*Corresponding Author:
Meenakshi Virmani
Department of Chemistry
Shri Jagdish Prasad Jhabarmal Tibrewala University
Jhunjhunu(333001), Churu Road
Chudela (Rajasthan), India.

Received: 01 March 2014 Accepted: 18 March 2014 Published: 24 March 2014

 

Abstract

A mixture of 4-hydroxyphenylacetic acid, absolute ethanol, few drops of concentrated sulphuric acid along with a small porcelain chip on reaction formed Ethyl-(4-hydroxyphenyl) acetate (1). On condensing mixture of (1), hydrazine hydrate and absolute ethanol formed 4-Hydroxyphenyl acetic acid hydrazide (2). Further mixture of 2, aryl/alkyl isothiocyanate and ethanol was refluxed and formed N1-[2-(4-Hydroxyphenyl) acetyl] N4-alkyl/aryl-3-thiosemicarbazide (3a-i). A suspension of (3a-3i) in ethanol, sodium hydroxide is refluxed for 2 hours on a water bath and formed 5-(Hydroxyphenyl) methyl-4-alkyl/aryl-2-mercpto-1,2,4(H)-triazoles (4a-i). The 1,2,4-triazole derivatives of 4-hydroxyphenyl acetic acid (4a-i) showed anti-inflammatory activity and Ibuprofen was taken as the standard drug

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