alexa Synthesis and Antimicrobial Activity of new (Z)-2-((5-(4-Hydroxybenzylidene)-4-Oxo-4,5 Dihydrothiazol-2-Yl)Amino) Acid and its Derivatives
e-ISSN: 2319-9849

Research & Reviews: Journal of Chemistry
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Research Article

Synthesis and Antimicrobial Activity of new (Z)-2-((5-(4-Hydroxybenzylidene)-4-Oxo-4,5 Dihydrothiazol-2-Yl)Amino) Acid and its Derivatives

Pansare Dattatraya N and Shinde Devanand B*

Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, MS, India.

*Corresponding Author:
Shinde Devanand B
Department of Chemical Technology
Dr. Babasaheb Ambedkar Marathwada University
Aurangabad 431 004, MS, India
Tel No: +91 0240-2403308
Fax No: +91 0240-2400413
E-mail: [email protected]

Received date: 12/3/2015; Accepted date: 28/3/2015; Published date: 31/3/2015



A series of (Z)-2-((5-(4-hydroxybenzylidene)-4-oxo-4,5-dihydrothiazol- 2-yl)amino) acid and its derivatives were synthesized from appropriate 2-thioxothiazolidin-4-one using nucleophilic substitution and Knoevenagel condensation. All compounds have been synthesized, characterized and screened for their antimicrobial activity against gram positive bacteria and gram negative bacteria along with Ampicillin and Ciprofloxacin as standard drug. According to results obtained all compound shows good to moderate activity against all strain tested, compatible to Ampicillin but lower than Ciprofloxacin. Amongst these compounds (6c) shows very good and moderate activity as compare to standards drugs against Gram positive bacteria B. subtilus and S. aureus. Some of the most potent compounds, namely (6b, 6h and 6j) possessed selectively antimicrobial activity.


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