alexa Synthesis of N-(substituted phenyl) pyrrolidine-2-carbo

Research & Reviews: Journal of Medicinal & Organic Chemistry
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Short Communication

Synthesis of N-(substituted phenyl) pyrrolidine-2-carboxamide as Novel Anticonvulsant Agents

Mohamed Jawed Ahsan1,2* and Mohd Amir1

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy Hamdard University, New Delhi 110062, India

2New Drug Discovery Research, Department of Pharmaceutical Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301 030, India

Corresponding Author:
Mohamed Jawed Ahsan
New Drug Discovery Research
Department of Medicinal Chemistry
Alwar Pharmacy College
Alwar, Rajasthan 301 030, India
E-mail: [email protected]

Received date: 01/10/2012 Revised date: 22/10/2012 Accepted date: 14/11/2012



In present investigation a series of N-(substituted phenyl) pyrrolidine-2-carboxamide derivatives were synthesized and were evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) test in mice. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Most of the compounds were found to be active in MES tests without any neurotoxicity. Compounds 3a and 3d were found the most active of the series without any neurotoxicity and less CNS depressant effect as compared to standard drug carbamazepine.


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