alexa Synthesis, Spectral Characterization of N-benzyl isatin
ISSN ONLINE(2319-8753)PRINT(2347-6710)

International Journal of Innovative Research in Science, Engineering and Technology
Open Access

Like us on: https://twitter.com/ijirset_r
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Synthesis, Spectral Characterization of N-benzyl isatin chiff base Cu(II), Co(II) and Ni(II) complexes and their effect on Cancer Cell lines

 
To read the full article Peer-reviewed Article PDF image

Abstract

The efficient antitumor drugs are ever demanding in the present scenario worldwide. The chemotherapeutic activity of isatin compounds can be achieved by chelation of transition metal ions with these bases and expanding in Nregion of these compounds. In this present study, two series of Cu(II), Co(II) and Ni(II) complexes with N-benzyl isatin and isonicotinohydrazide Schiff base ligand (L1) have been synthesized and characterized by using the modern analytical techniques such as IR, NMR, UV-visible, Mass, CV, and EPR etc. All the complexes are soluble in DMF and DMSO. Elemental analysis and molar conductance values indicate that the complexes are non-electrolytes. All the complexes adopt octahedral geometry around the metal ions. DNA binding activities of the complexes Cu(II), Co(II) and Ni(II) are studied by UV-vis and also cleavage studies of complexes have been done by agarose gel electrophoresis method. Cytotoxicity experiments carried out toward human AGS-gastric cancer cell line. Interestingly, compound, L1- Ni was found to be excellent anticancer activity against AGS-gastric cancer cell line.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords