alexa Tau Protein and its Phosphorylation: Alzheimer?s Disease
ISSN: 2319-9865

Research & Reviews: Journal of Medical and Health Sciences
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Review Article

Tau Protein and its Phosphorylation: Alzheimer?s Disease

Sunil Kumar Singh1*,Nisha Dhama2,Arif Khan1,Gaurav Singh3

Department of Biosciences and Technology,VIT University,Vellore,Tamil Nadu,India

Department of Biotechnology,Meerut Institute of Engineering & Technology,Meerut,U.P,India

Department of Bioinformatics,IIIT University,Hyderabad,Telangana State,India

*Corresponding Author:
Sunil Kumar Singh
Department of Biosciences and Technology,VIT University,Vellore,Tamil Nadu,India
Tel: +91 9966661052
[email protected]

Received date: 20/03/2015 Accepted date: 23/04/2015



The alterations of insulin signaling, calcium signaling, mitochondrial deterioration and oxidative strain have been associated in the hyperphosphorylation of tau protein found in Downs syndrome dementia. Such sorts of pathogenic etiologies have clear ramifications in the counteractive action and treatment of Down's disorder (DS) dementia. The event of methylation abandons in DS is examined yet despite the fact that dubious, later studies do show criticalness. Kinases, for example, DYK1A and GlcNAcylation are examined and a Cdk5 inhibitory peptide (CIP). Indeed, even rest drug has been shown in that seniors, who have better rest, endure less subjective decay than those with slumber issues with upgraded leeway of β amyloid and tau neurofibrillary tangles. Studies have reported a high rate of slumber issues in Down's. Ecological poison arsenite and low dosage methyl mercury have been conjectured to prompt tau phosphorylation. Dietary changes to low glycemic carb and gluten shirking ought to be made. Including B vitamins may be similarly critical to avert cerebrum decay particularly in those with MTHFR and MTRR quality deformities. The remedial system of diminishing insulin resistance by up regulation of PPARS alpha with glitazones and diminishing calcium inundation into the mitochondria is said. Shielding mitochondrial decrease from oxidative anxiety with cancer prevention agents, and treatment with CBD, polyphenols, ellagic corrosive, resveratrol and other grape bioflavinoids and moderate attractive fields is examined.


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