alexa Celiac Disease|Omics Publishing Group|Pharmaceutica Analytica Acta

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Celiac Disease

Pharmaceutical analysis may be defined as a procedure or the sequences of progressions to identify or quantify a constituent or drug, the mechanisms of a pharmaceutical solution or fusion or the determination of the structures of chemical combinations used in the formulation of pharmaceutical product. Celiac disease (CD) is a gluten-sensitive, immune–mediated chronic enteropathy with a wide range of manifestations of variable severity. This disease is due to the damage of intestinal mucosa as a result of the action of gluten, in genetic predisposed people. The masks that can diagnose celiac disease, presented below, are divided into: classical Celiac disease, non-classical Celiac disease, subclinical Celiac disease and potential Celiac disease. The clinical manifestations and histology changes of small bowel mucosa will disappear with gluten-free diet, but histological relapses will appear in a variable period of time after re-use of foods with gluten. Prevalence of this disorder is difficult to estimate due to the variability of clinical presentation. Lifelong avoidance of gluten ingestion is the main treatment for patients with celiac disease. It is characterized by gastrointestinal signs and symptoms. Typical form of the disease begins at various times after foods that contain gluten are introduced into the diet. Characteristic manifestations of infants and young children are chronic diarrhea, vomiting, anorexia, abdominal distention, abdominal pain, and poor weight gain or weight loss. Nutritional deficiency syndrome occurs in time and its manifestations are: growth deficiency, psychomotor development deficiency, anemia, rickets, and hemorrhagic manifestations. Undiagnosed and severely affected infants may present celiac crisis characterized by explosive diarrhea, marked abdominal distention, dehydration and lethargy. Delayed diagnosis and persistent symptoms can cause severe malnutrition
 
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