Perfluorochemicals Articles|OMICS International|Pharmaceutica Analytica Acta

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Pharmaceutical analysis may be defined as a procedure or the sequences of progressions to identify or quantify a constituent or drug, the mechanisms of a pharmaceutical solution or fusion or the determination of the structures of chemical combinations used in the formulation of pharmaceutical product. Perfluorochemicals can dissolve significant quantities of many gases including oxygen (O2) and carbon dioxide (CO2). Optimal use of artificial blood substitutes such as perfluorocarbon emulsions in conjunction with 100% oxygen ventilation are valuable to patients with relatively low hemoglobin levels. Perfluorochemicals are hydrophobic, then stable perfluorocarbon emulsion with exceptionally smaller particles have been generated for intravenous use. While the metabolism of fluorocarbon molecules is still unclear in humans, it seems that after intravenous administration, the droplets of perfluorocarbon emulsions are taken up by the reticulo-endothelial system (RES) before being slowly broken down and transported by the blood to the lungs where the unaltered perfluorocarbon molecules are finally excreted via exhalation. The intravascular half-life of perfluorocarbons, determined by the RES uptake and the dose used, is relatively short. In order to characterize qualitatively and quantitatively perfluorocarbons and its derived products. we used an innovative and powerful technology named carbon-fluorine spectroscopy.
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Last date updated on March, 2021