Transfersomes|OMICS International|Pharmaceutica Analytica Acta

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Pharmaceutical analysis may be defined as a procedure or the sequences of progressions to identify or quantify a constituent or drug, the mechanisms of a pharmaceutical solution or fusion or the determination of the structures of chemical combinations used in the formulation of pharmaceutical product. Transfersomes (TF), alias ultradeformable nano-liposomes, were obtained by adding surfactants (such as sodium cholate, etc) in phospholipid bilayers of conventional liposomes. Besides advantages of the good affinity with skin, innocuity and safety, the priorities associated with transfersomes were their high deformability and high skin penetration. The drugs transfer across the skin from the epidermis into the dermis and finally into lymphatic vessels and blood vessels, and possess a therapeutic effect. Lappaconitine hydrobromide (LH) was an alkaloidal hydrobromate extracted from the roots of Aconitum Sinomontanum Nakai.The molecular weight and melting point of LH were 683.64 Dalton and 217-221°C, respectively. LH was soluble in methanol and hexane, slightly soluble in water, very slightly soluble in ethanol, but practically insoluble in chloroform. Due to the relatively strong analgesic effect. Due to the relatively strong analgesic effect, LH was a good non-addictive anodyne and an effective therapy for various pain symptoms in clinic, such as postoperative pain, gastrointestinal ulcer, gastritis, hepatitis, rheumatoid arthritis, sciatica, headache caused by cold and so on.
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Last date updated on May, 2021