Pharmacogenetics studies have focused on drug-metabolizing enzymes and membrane drug transporters to provide a better understanding of the mechanism underlying the interindividual variations in drug exposure and response. Despite of the high number of genetic polymorphisms discovered over the past few years, only a few of them became of clinical significance. In this review, the most relevant genetic polymorphisms affecting the activity and/or the expression of key drug-metabolizing enzymes and membrane drug transporters are summarized. Sonia RodrÃguez NÃ³voa, The Pharmacogenetics of HIV Treatment: A Practical Clinical Approach.
Last date updated on June, 2014