|Use of pharmacogenomics principles have become a staple part during early drug discovery processes. Its application continues during preclinical and clinical drug development. Absorption, Distribution, Metabolism, Elimination (ADME) chip like DMETâ¢ Plus Solution Kits are now routinely used for profiling metabolic pathways. These chips include some of the well-known variants in transporter genes, metabolizing enzymes like CYPs, safety/efficacy biomarkers and population specific biomarkers. This represents how drug discovery efforts based on pharmacogenomics are directly applied to pharmacology, translational as well as preclinical and clinical research. Deepak Gupta, Pharmacogenomics in Drug Discovery and Development.