Advances in genotyping technologies have made it possible for the field of pharmacogenetics (the study of genetic variability in individual responses to drugs) to assume its place of importance in the medical field. Then pharmacogenetics has evolved into pharmacogenomics (the study of the roles on inherited and acquired genetic variations in drug responses) with a shift from a focus on individual candidate genes to a more comprehensive approach using Genome-Wide Association Studies (GWAS). This shift has led to the identification of genetic variations of Single Nucleotide Polymorphisms (SNPs) in the region of many genes that may play a critical role in predicting treatment response in patients at various disease states. Sayed S Daoud, Hepatitis C Pharmacogenetics: Possible Solutions for an Existing Problem.
Last date updated on June, 2014