Individual drug response results to be highly variable among treated patients for many of the most commonly prescribed drugs. Common sequence variants in the human genome are today believed to be the main cause of different individual drug response. Pharmacogenomics applies the principles of both pharmacology and genetics, for the discovery and validation of functional gene polymorphisms that could be relevant in the modulation of the pharmacodynamics and pharmacokinetics of drugs, in order to be able to predict the personal response to drugs both in terms of beneficial and adverse effects. Maria Luisa Brandi, Pharmacogenetics of Metabolic Bone Diseases.
Last date updated on June, 2014