Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Primary goals of clinical pharmacokinetics include enhancing efficacy and decreasing toxicity of a patientâs drug therapy. The development of strong correlations between drug concentrations and their pharmacologic responses has enabled clinicians to apply pharmacokinetic principles to actual patient situations. Of particular interest are changes in kinetic parameters with dose (dose-dependent kinetics) within the recommended clinical dosing range. When appropriate, other information may include influences of demographic characteristics like age sex and race, influence of certain diseases states, influence of external factors such as meals or other drugs (drug-drug pharmacokinetics), drug binding to biological constituents like plasma proteins and RBC, studies performed in special patientâs populations and studies performed under conditions of therapeutic use.
Last date updated on September, 2014