|Epigallocatechin is a primary polyphenol content of green tea, and it is a kind of natural antioxidant. It can transfer through the blood-brain-barrier (BBB), protect nerve cells from injuries caused by free radical, and potentially treat neural damages. EGCG could improve function recovery after SCI and protect injured tissues from further damages. EGCG had an obvious effect against edema after SCI and further succeeded in curing secondary SCI, but the mechanism is still unknown.With further understanding of various signaling pathways, advances have been made in blocking certain signaling pathways for the treatment of secondary damage following SCI. Aquaporin- 4(AQP4) is the most abundant water channel protein in the central neural system and plays a major role in regulating water balance in spinal cord. Mitogen-activated protein kinase (MAPK) is the most important signaling system in mammalian cells and is involved in the regulation of cell edema, proliferation, development, differentiation and inflammation.
Anti-Edema Effect of Epigallocatechin against Acute Spinal Cord Injury in Rats and its Correlation with the P38MAPK/NF-Îºb Signaling Pathway: Yue Zhu