|"Preeclampsia, affecting 2-7% of all pregnancies, is a vasculopathy that results from aberrant placenta development and it is the third highest cause of pregnancy related deaths following hemorrhage and embolism. While the etiology of preeclampsia is poorly understood, a leading theory is that insufficient spiral artery remodeling in the placenta may result in a hypoxic environment with reperfusion injury and up-regulation of oxidative stress. The preeclamptic lacenta secretes factors such as inflammatory cytokines and reactive oxygen species into maternal circulation to induce hypertension through local production of vasoconstrictors, notably endothelin-1. As a result, the mother shows signs of preeclampsia after the 20th week of gestation by new onset hypertension and proteinuria.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."