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Prion Diseases
"In 2013, there are other researches on rabbits for diseased prions (PrPSc). Wang et al. (2013) aimed to investigate âpotential mechanisms contributing to prion resistance or susceptibility by using the rabbit, a species unsusceptible to prion infection, as a model and investigated âthe expression level and distribution of LRP/LR (laminin receptor precursor or laminin receptor) in rabbit tissues by real-time polymerase chain reaction and by immunochemical analysis with a monoclonal anti-67 kDa LR antibody âand at last their findings confirmed the prion resistance in rabbits. Sweeting et al. (2013) produced X-ray structures of mutants in the β2-α2 loop and reported that the helixcapping motif in the β2-α2 loop modulates β-state misfolding in RaPrP, and still acknowledged ârabbit PrP, a resistant speciesâ.
(Recent Advances in the Immunity Research of Rabbits to Prion Diseases : Jiapu Zhang)
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Last date updated on December, 2020