"Prions accumulate quickly in the lymph nodes and remain there throughout the extended asymptomatic period, whereas they only accumulate in the brain in the later stages of the disease. Incubation periods vary greatly based on species. Incubation times for experimental sheep scrapie are normally 1-2 years, while humans can incubate prion disease in excess of 50 years before showing any clinical signs. Therefore, it may eventually be possible to treat prion diseases after infection but before PrPSc accumulation has been established in the brain. As long as accumulation in the brain is inhibited, the host appears to suffer no ill effects from the disease. (Recent Advances in the Immunity Research of Rabbits to Prion Diseases: Jiapu Zhang)
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Last date updated on June, 2014