Proteases are essential constituents of all forms of life on earth including prokaryotes, fungi, plants and animals. Proteases are highly exploited enzymes in food, leather, detergent, pharmaceutical, diagnostics, waste management and silver recovery. Proteases constitute one of the most important groups of industrial enzymes, accounting for about 60% of the total enzyme market. Among the various proteases, bacterial proteases are the most significant, compared with animal and fungal proteases and among bacteria, Bacillus sp. are specific producers of extra-cellular protease. These enzymes have wide industrial application, including pharmaceutical industry, leather industry, and manufacture of protein hydrolysis, food industry and waste processing industry. Thermo-stable proteases are advantageous in some applications because higher processing temperature can be employed, resulting in faster reaction rates, increase in the solubility of nongaseous reactants and products and reduced incidence of microbial contamination by mesophilic organisms. Proteases secreted from thermophilic bacteria are thus of particular interest and have become more useful in a range of commercial applications.
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Last date updated on June, 2014