"Recent genome sequencing projects have provided massive amount of data, however, many of these genomes are still not fully annotated and consist of genes/proteins with unknown function and structure. This is due to several limitations, such as the cost and time required for experimental approaches. An alternative to laboratory based methods is a bioinformatics approach that utilizes algorithms and databases to estimate protein function. As these algorithms and at a bases are based on experimental results, they can be an effective means to perform functional and structural annotation of hypothetical proteins. Structures are more evolutionary conserved than sequence; therefore, analysis of three-dimensional (3D) structures holds great potential. Our present study describes the three 3D models of rbc L protein sequences which found conserved in multiple sequence alignment and further three protein structure predicted through homology modelling. In addition sequence and structural analysis and un-functional annotation were also done.
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Last date updated on July, 2014