"The proteomic analysis of amyloid deposits from the three cases of eyelid amyloidosis resulted in 35, 92 and 74 protein hits of which 31, 83 and 64 were endogenous proteins from specimen 1, 2 and 3, respectively (supplementary). Only proteins identified in both technical replicates were accepted. From the eyelid non-amyloid control tissue we obtained 32, 57 and 49 protein hits for specimen 1, 2 and 3, respectively, of which 23, 49 and 38 were endogenous proteins. In the eyelid amyloid deposits several proteins were enriched compared to yelid control tissue indicating that they accumulated in the deposits. he most abundant component of the eyelid amyloid deposits from specimen 1 was Ig kappa chain C region, whereas Ig lambda-2 chain C regions was accumulated in the amyloid deposits from specimen 2 and 3.
OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the support of 50,000+ editorial board members as editorial team and aimed to disseminate the scholarly knowledge to the scientific society. OMICS Group also organizing 3000+ International Scientific Conferences and events yearly all over the world with the support of 1000+ Scientific associations worldwide.
Citation: Nielsen NS, Poulsen ET, Klintworth GK, Enghild JJ (2014) Insight into the
Protein Composition of Immunoglobulin Light Chain Deposits of Eyelid, Orbital and
Conjunctival Amyloidosis. J Proteomics Bioinform S8: 002"
Last date updated on July, 2014