"Proteomics offers a promising alternative to classical candidate based approaches for identifying biomarkers of preeclampsia because of its ability to detect the whole protein complement. Additionally, the ability to investigate changes in placental tissue, its secreted fraction and maternal serum enable the elucidation of placental dysfunction and maternal responses underlying the origins and mechanisms behind this pathology. Altered plasma proteins may be a result of factors directly secreted from the placenta or a maternal response triggered against the aberrant placenta. Comparing proteins found in the tissue and serum will elude to how the placenta causes systemic maternal vascular dysfunction.
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Last date updated on September, 2020