Lung cancer is the first cause of mortality from malignancy worldwide. Adenocarcinoma of the lung (LADC) patients increased in number in the past few decades [1,2]. According to 2004, World Health Organization lung carcinoma classification, adenocarcinoma is defined as malignant epithelial tumor with glandular morphological pattern or mucus secretion. They show acinar, papillar, solid, bronchioloalveolar or mixture pattern. International Association for the Study of Lung Cancer excluded bronchiloalveolar carcinoma and mixture morphological pattern of adenocarcinoma in use. Invasive adenocarcinoma of the lung included: lepidic, acinar, papillary, micropapillary and solid subtypes [3,4].
Despite of growth pattern of LADC, its immunophenotype remained the same. In diagnostic algorithm of LADC is emphasized the significance of Thyreoid-Transcriptive-Factor-1 (TTF-1) for differentiation LADC from the other non-small cell lung carcinoma. Cytokeratin7 confirmed lung origin of adenocarcinoma, excluding digestive system origin. Terry et al. suggested TTF-1, Cytokeratin7 and Napsin-A for differentiation adenocarcinoma of the lung from squamous cell carcinoma. Napsin-A and Surfactant B with high specificity for adenocarcinoma of the lung confirm its origin.
Immunohistochemical Approach to the Diagnosis of Adenocarcinoma of the Lung
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Last date updated on November, 2020