Obstructive sleep apnea (OSA) is a good pathophysiological model of the non-dipping phenomenon. A ânon-dippingâ pattern was found in 48â84% of OSA patients and the frequency increases with its severity. The nocturnal BP profile in non-dipper hypertensive patients is strikingly similar to that described in studies of 24h-BP measurements in patients with OSA. OSA itself is assumed as a new cardiovascular disease, compilating both the negative consequences of sympathetic over activation, sleep disruption, autonomic dysregulation and metabolic derangements. Under such conditions the detection of non-dippers and the strict management of their blood pressure control is undoubtedly pursued.
Clinical Factors and Biomarkers Associated with the Non-Dipping Profile in Obstructive Sleep Apnea Patients with Metabolic Syndrome: Radostina Vlaeva Cherneva, Ognian Borisov Georgiev, Daniela Stoichkova Petrova, Emil Ivanov Mano, Adelina Dimitrova Tsakova and Julia Ivanova Petrova
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Last date updated on July, 2014