"Reactive oxygen species (ROS) or reactive nitrogen species (RNS) are continuously produced under various conditions, leading to an imbalance of cellular redox homeostasis, which is both physiologically necessary and potentially destructive. Although ROS and RNS are generated in lower amounts within cell under physiological conditions, they play an integral role in modulation of cellular functions including metabolism, gene expression, signal transduction, vasorelaxation, defense against invading pathogens, andso on. The major targets of ROS/RNS in living cells are proteinsthat are capable of scavenging 50~75% of reactive radicals, which consequently cause distinct post-translational modifications (PTMs) on proteins and further modulate many biological responses. Among the protein residues modified during the imbalanceof redox states, the sulphur-containing residues, cysteine (Cys) andmethionine (Met), are most susceptible to attacks by radicals.
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Citation: Hu Q, Guo G, Yang Z, Li Y, Xia Y (2014) Stable Isotope Metabolic Labeling-Based Quantitative Thiol Redox Proteomic Analysis of Hydrogen Peroxide-treated Arabidopsis plant. J Proteomics Bioinform 7: 121-133."
Last date updated on July, 2014