Regucalcin, which was discovered in 1978, plays a multifunctional role as a suppressor protein in signal transduction in various cell types and plays a cell physiologic role in maintaining cell homeostasis for various stimuli. Cytoplasmic regucalcin localizes into the nucleus, and it suppresses nuclear protein kinase and protein phosphatase activities and DNA and RNA synthesis and regulates gene expression for various proteins. Regucalcin has also been shown to suppress protein synthesis and activate proteolysis, suggesting a role as suppressor in protein turnover. Moreover, overexpression of endogenous regucalcin has been demonstrated to suppress cell proliferation and apoptosis induced through multisignaling pathways in various cell types. Thus, regucalcin plays a pivotal role in cell regulation.
New Aspects in Obesity and Diabetes: Involvement in Regucalcin, a Suppressor Protein of Cell Signaling- Masayoshi Yamaguchi
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Last date updated on June, 2014