Human conceptus is a semi-allograft and hence antigenically foreign to the mother, the process of implantation may include mechanisms preventing allograft rejection, once the immunological tolerance is imbalanced, pathological pregnancy, such as spontaneous abortion would occur. Recurrent Pregnancy Loss (RPL) is a disease, defined by two or more failed pregnancies, affecting about 5% pregnant women. RPL can be classified into primary RPL and secondary RPL. Primary RPL aborters are those who have lost all previous pregnancies and have no live birth. Secondary RPL aborters are those who have at least one successful pregnancy, irrespective of the number of pregnancy losses. In 50% to 75% of couples with recurrent pregnancy losses, the etiology is Unknown (URPL), although genetic/chromosomal causes, hormonal abnormalities, metabolic abnormalities, uterine abnormalities, anti-phospholipid syndrome, thrombophilias, male factor have been implicated. URPL is considered to be a model of immunological rejection of the fetus by the mother. Immunomodulatory therapies may improve the live birth rate in appropriately selected patients, its efficiency need further investigation. It is important to have better diagnosis of subsets that benefit from LIT before LIT indicated in the URPL aborters. Lymphocyte Immunotherapy is Not Necessary for Primary Unexplained Abortions, Wen Juan Wang.
Last date updated on June, 2021