The etiology of ovarian cancer is still unclear. Interactions of environmental factors, interactions of genes, and gene environment interactions may play an important role in the development of ovarian cancer. A large number of studies have been conducted for numerous genes and also for all common cancer sites, although results have been very inconsistent and therefore inconclusive. There is also much confusion about the meaning of âgeneâenvironment interactionâ, what type of studies should be conducted to pinpoint the mechanism and also how it should be measured. Furthermore, the very purpose of those studies is not clear; are they attempting to identify high-risk individuals, or are they simply trying to further understand the cancer process? Hence, further investigations are required to identify association of OCP with the incidence of ovarian cancer and high risk phenotypes. Such investigation will provide an evidence of gene-environment interaction and high risk phenotypes in the pathogenesis of ovarian cancer and will also highlight the importance of individual genetic susceptibility to ovarian cancer following exposure to environmental toxins. Gene-Environment Interaction and Risk of Ovarian Cancer, Basu Dev Banerjee and Tusha Sharma.
Last date updated on June, 2014